Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.45 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.45 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978051 | 0.87 | HSD17B10 (0.46) | ALDH1A1HPGDMAPTSMN1; SMN2TDP1 | |
| SCHEMBL749155 | 0.76 | CRHBP (0.53) | CRHBPCRHR2ALDH1A1HPGDMAPT | |
| SCHEMBL12055674 | 0.73 | CRHBP (0.50) | CRHBPCRHR2ALDH1A1HPGDMAPT | |
| SCHEMBL8388159 | 0.72 | KDM4E (0.42) | ALDH1A1HPGDMAPTSMN1; SMN2TDP1 | |
| SCHEMBL1091355 | 0.72 | HSD17B10 (0.52) | ALDH1A1MAPTTDP1TSHRHSD17B10 | |
| SCHEMBL29595163 | 0.72 | HSD17B10 (0.52) | ALDH1A1MAPTTDP1TSHRHSD17B10 | |
| SCHEMBL6766590 | 0.71 | MIF (0.39) | ALDH1A1HPGDMAPTSMN1; SMN2TDP1 | |
| SCHEMBL17037126 | 0.70 | CRHBP (0.47) | CRHBPCRHR2ALDH1A1HPGDMAPT | |
| SCHEMBL7963908 | 0.70 | CRHBP (0.39) | CRHBPCRHR2ALDH1A1HPGDMAPT | |
| SCHEMBL6589360 | 0.70 | TXNRD1 (0.49) | ALDH1A1HPGDMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3606921-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. | Inventiva (FR) | 2020-02-12 | — | — | EP | disclosed |
| WO-2018185266-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. | INVENTIVA (FR) | 2018-10-11 | — | — | WO | disclosed |