Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20529629 | 1.00 | MAPT (0.65) | MAPTLMNAALOX12CYP1A2CYP2C19 | |
| SCHEMBL20529635 | 0.83 | SMN1; SMN2 (0.57) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20529633 | 0.83 | SMN1; SMN2 (0.57) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20109301 | 0.83 | ALDH1A1 (0.59) | MAPTLMNAALOX12SMN1; SMN2MEN1 | |
| SCHEMBL31192807 | 0.83 | ALDH1A1 (0.59) | MAPTLMNAALOX12SMN1; SMN2MEN1 | |
| SCHEMBL20529687 | 0.81 | GAA (0.61) | MAPTLMNAALOX12SMN1; SMN2MEN1 | |
| SCHEMBL20529688 | 0.81 | GAA (0.61) | MAPTLMNAALOX12SMN1; SMN2MEN1 | |
| SCHEMBL11072927 | 0.79 | CYP1A2 (0.74) | MAPTLMNAALOX12CYP1A2CYP2C19 | |
| SCHEMBL8956609 | 0.78 | CYP1A2 (0.79) | MAPTLMNAALOX12CYP1A2CYP2C19 | |
| SCHEMBL5455602 | 0.75 | MAPT (0.83) | MAPTLMNACYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018187414-A1 | INHIBITORS OF MTOR-RICTOR INTERACTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-10-11 | — | — | WO | disclosed |