Sugi Predict

Sugi Predict / Compounds / SCHEMBL20529669

SCHEMBL20529669

SCHEMBL20529669

FC(F)(F)Cn1nnc2ccc(Br)cc21

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TDO2 P48775 2/20 0.51
▸ MGAM O43451 2/20 0.38
▸ AMY1A P0DUB6 2/20 0.38
▸ GAA P10253 2/20 0.38
▸ SI P14410 2/20 0.38
▸ MGAM2 Q2M2H8 2/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ AR P10275 2/20 0.37
▸ PTK2 Q05397 5/20 0.36
▸ KMO O15229 1/20 0.35
▸ SLC9A1 P19634 3/20 0.34
▸ NT5E P21589 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ GRM2 Q14416 1/20 0.33
▸ PDE2A O00408 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30699124 0.81 AR (0.40) TDO2MGAMAMY1AGAASI
SCHEMBL22155665 0.79 MGAM (0.38) TDO2MGAMAMY1AGAASI
SCHEMBL20529652 0.78 SLC9A1 (0.58) MGAMAMY1AGAASIMGAM2
SCHEMBL31473638 0.78 SLC9A1 (0.58) MGAMAMY1AGAASIMGAM2
SCHEMBL20529671 0.77 MGAM (0.38) TDO2MGAMAMY1AGAASI
SCHEMBL30349421 0.77 MGAM (0.38) TDO2MGAMAMY1AGAASI
SCHEMBL20529702 0.76 TDO2 (0.56) TDO2MGAMAMY1AGAASI
SCHEMBL31642496 0.75 SLC9A1 (0.60) MGAMAMY1AGAASIMGAM2
SCHEMBL24024564 0.73 TDO2 (0.53) TDO2
SCHEMBL20529667 0.73 TDO2 (0.53) TDO2GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206746-A1 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF TENARX, INC. 2025-06-26 — — US disclosed
WO-2025137469-A1 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF BIOSPLICE THERAPEUTICS, INC. (US) 2025-06-26 — — WO disclosed
US-20240002391-A1 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF TENARX, INC. 2024-01-04 — — US disclosed
WO-2023250156-A1 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF BIOSPLICE THERAPEUTICS, INC. (US) 2023-12-28 — — WO disclosed
US-11731966-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2023-08-22 — — US disclosed
US-11731966-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2023-08-22 — — US disclosed
WO-2018187480-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-10-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11731966-B2 Compounds and their methods of use SCN1A, SCN3A, SCN1B TDO2 4221/4885MGAM 4124/4885AMY1A 4636/4885
US-20240002391-A1 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK2, DYRK1B TDO2 690/4885MGAM 4100/4885AMY1A 1561/4885
US-20250206746-A1 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK2, DYRK1B TDO2 690/4885MGAM 4100/4885AMY1A 1561/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.