Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28635550 | 0.83 | KDM4E (0.35) | KDM4EGLAGPR35DPP4MAPT | |
| SCHEMBL10409265 | 0.78 | KDM4E (0.37) | KDM4EGLADPP4MAPTALDH1A1 | |
| SCHEMBL24625576 | 0.78 | CASP1 (0.33) | GLAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL26050621 | 0.77 | CYP2A6 (0.40) | DPP4 | |
| SCHEMBL26931423 | 0.76 | DPP4 (0.49) | DPP4POLBALDH1A1MEN1KMT2A | |
| SCHEMBL30682755 | 0.76 | DPP4 (0.49) | DPP4POLBALDH1A1MEN1KMT2A | |
| SCHEMBL31310646 | 0.76 | KDM4E (0.39) | KDM4EGLAMAPTPOLBPLAU | |
| SCHEMBL19970560 | 0.75 | KDM4E (0.41) | KDM4EGLAGPR35MAPTPOLB | |
| SCHEMBL2262110 | 0.74 | KDM4E (0.34) | KDM4EGLAMAPTALDH1A1MEN1 | |
| SCHEMBL423154 | 0.73 | CYP2A6 (0.46) | KDM4EGLAGPR35MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018187480-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-10-11 | — | — | WO | disclosed |