SCHEMBL20529795

SCHEMBL20529795

FC(F)(F)c1nc(-c2ccc(CCl)cc2)no1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 18/20 0.60
HDAC1 Q13547 12/20 0.60
HDAC8 Q9BY41 12/20 0.60
HDAC4 P56524 7/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18824381 0.86 HDAC4 (0.66) HDAC6HDAC1HDAC8HDAC4
SCHEMBL18795958 0.84 HDAC6 (0.60) HDAC6HDAC1HDAC8HDAC4
SCHEMBL19463719 0.84 HDAC6 (0.65) HDAC6HDAC1HDAC8HDAC4
SCHEMBL28862079 0.84 HDAC6 (0.60) HDAC6HDAC1HDAC8HDAC4
SCHEMBL20471101 0.84 HDAC4 (0.64) HDAC6HDAC1HDAC8HDAC4
SCHEMBL8360856 0.84 HDAC6 (0.60) HDAC6HDAC1HDAC8HDAC4
Hydrochloric Acid SCHEMBL18422626 0.83 HDAC6 (0.59) HDAC6HDAC1HDAC8HDAC4
Bromide SCHEMBL29373726 0.83 HDAC6 (0.59) HDAC6HDAC1HDAC8HDAC4
SCHEMBL20529810 0.82 HDAC6 (0.59) HDAC6HDAC1HDAC8HDAC4
SCHEMBL20529840 0.82 HDAC6 (0.58) HDAC6HDAC1HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606548-B2 Fungicidal oxadiazoles FMC CORPORATION (US) 2026-04-21 US disclosed
US-20240166638-A1 FUNGICIDAL OXADIAZOLES FMC CORP (US) 2024-05-23 US disclosed
CN-118047771-A Fungicidal oxadiazoles FMC公司 2024-05-17 CN disclosed
CN-118047729-A Fungicidal oxadiazoles FMC公司 2024-05-17 CN disclosed
EP-4361150-A2 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC Corporation (US) 2024-05-01 EP disclosed
US-20240090503-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION 2024-03-21 US disclosed
CN-110650956-B Fungicidal oxadiazoles FMC公司 2024-03-08 CN disclosed
EP-4262396-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION (US) 2023-10-25 EP disclosed
CN-116634874-A Fungicidal oxadiazoles and mixtures thereof FMC公司 2023-08-22 CN disclosed
US-11708358-B2 Fungicidal oxadiazoles FMC CORPORATION (US) 2023-07-25 US disclosed
WO-2022133114-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION (US) 2022-06-23 WO disclosed
EP-3957636-A1 FUNGICIDAL OXADIAZOLES FMC Corporation (US) 2022-02-23 EP disclosed
EP-3606920-B1 FUNGICIDAL OXADIAZOLES FMC CORP (US) 2021-09-22 EP disclosed
US-20200148672-A1 FUNGICIDAL OXADIAZOLES FMC CORPORATION 2020-05-14 US disclosed
EP-3606920-A1 FUNGICIDAL OXADIAZOLES FMC Corporation (US) 2020-02-12 EP disclosed
CN-110650956-A Fungicidal oxadiazoles FMC公司 2020-01-03 CN disclosed
WO-2018187553-A1 FUNGICIDAL OXADIAZOLES FMC CORPORATION (US) 2018-10-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240166638-A1 FUNGICIDAL OXADIAZOLES OXA1L, NOX1, TH HDAC6 1038/4885HDAC1 1586/4885HDAC8 2957/4885
US-12606548-B2 Fungicidal oxadiazoles AOC2, AOC3, MT-CO3 HDAC6 1102/4885HDAC1 2753/4885HDAC8 3176/4885
US-20200148672-A1 FUNGICIDAL OXADIAZOLES OXA1L, NOX1, TH HDAC6 1038/4885HDAC1 1586/4885HDAC8 2957/4885
US-20240090503-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES NOX1, TH, NOX3 HDAC6 487/4885HDAC1 888/4885HDAC8 2171/4885
US-11708358-B2 Fungicidal oxadiazoles OXA1L, NOX1, TH HDAC6 1038/4885HDAC1 1586/4885HDAC8 2957/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.