Camiglibose

Camiglibose

SCHEMBL2052995

CO[C@H]1O[C@H](CN2CC(O)C(O)C(O)C2CO)[C@@H](O)[C@H](O)[C@H]1O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 9/20 0.50
MGAM O43451 8/20 0.50
SI P14410 3/20 0.46
GBA1 P04062 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
LCT P09848 1/20 0.46
GBA2 Q9HCG7 7/20 0.46
UGCG Q16739 3/20 0.46
AGL P35573 2/20 0.46
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
MAPK1 P28482 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Camiglibose SCHEMBL19510347 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL1201508 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL3952283 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL5186895 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL4604473 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL758524 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL5238483 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL614436 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL6794338 1.00 GAA (0.50) GAAMGAMSIGBA1TDP1
Camiglibose SCHEMBL37446 0.99 GAA (0.49) GAAMGAMSIGBA1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2506865-A2 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, CORONARY HEART DISEASE, GALLSTONE, OBESITY AND OTHER CARDIOVASCULAR DISEASES Synergy Pharmaceuticals Inc. (US) 2012-10-10 EP disclosed
WO-2011069038-A2 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, CORONARY HEART DISEASE, GALLSTONE, OBESITY AND OTHER CARDIOVASCULAR DISEASES SYNERGY PHARMACEUTICALS, INC. (US) 2011-06-09 WO disclosed
EP-1753766-A1 TETRAAZABENZO(E)AZULENE DERIVATIVES AND ANALOGS THEREOF Pfizer Products Inc. (US) 2007-02-21 EP disclosed
WO-2006033001-A1 QUINOLINE COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-03-30 WO disclosed
WO-2005116034-A1 TETRAAZABENZO[E]AZULENE DERIVATIVES AND ANALOGS THEREOF PFIZER PRODUCTS INC. (US) 2005-12-08 WO disclosed
EP-1372632-A1 PROLIFERATIVE ACTIVATOR RECEPTOR (PPAR) COMPOUNDS Pfizer Products Inc. (US) 2004-01-02 EP disclosed
WO-2002064130-A1 PROLIFERATIVE ACTIVATOR RECEPTOR (PPAR) COMPOUNDS PFIZER PRODUCTS INC. (US) 2002-08-22 WO disclosed