Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | POLR1A | O95602 | 1/20 | 0.36 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530303 | 0.96 | MET (0.49) | METL3MBTL1KDM4ETET3TET2 | |
| SCHEMBL20530325 | 0.92 | MEN1 (0.41) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL20530350 | 0.91 | MEN1 (0.41) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL20530357 | 0.90 | MEN1 (0.42) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL20530342 | 0.90 | MET (0.41) | METKDM4EMEN1NPC1RAB9A | |
| SCHEMBL20530343 | 0.89 | BRAF (0.41) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL20530315 | 0.89 | MET (0.40) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL20530351 | 0.88 | GRIN2B (0.39) | METKDM4EMEN1NPC1RAB9A | |
| SCHEMBL20530324 | 0.88 | L3MBTL1 (0.52) | L3MBTL1KDM4ETET3TET2TET1 | |
| SCHEMBL1329316 | 0.88 | MET (0.56) | METCDKL5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |