Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.52 |
| ▸ | PRF1 | P14222 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 10/20 | 0.40 |
| ▸ | MAOB | P27338 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014659 | 0.90 | NOTUM (0.52) | NOTUMPRF1ACHEMAPT | |
| SCHEMBL17055774 | 0.71 | NOTUM (0.56) | NOTUMMAPTSMN1; SMN2 | |
| SCHEMBL1638547 | 0.70 | PRF1 (0.54) | PRF1ACHEMAOAMAOB | |
| SCHEMBL1313626 | 0.70 | NOTUM (1.00) | NOTUMMAPTSMN1; SMN2CYP2C9 | |
| SCHEMBL190291 | 0.69 | NOTUM (0.72) | NOTUMMAPTSMN1; SMN2P2RY14CYP2C9 | |
| SCHEMBL17580040 | 0.69 | MAOA (0.57) | PRF1MAOAMAOBMAPTSMN1; SMN2 | |
| SCHEMBL3233333 | 0.69 | NOTUM (0.72) | NOTUMSMN1; SMN2P2RY14CYP2C9TSPO | |
| SCHEMBL4683349 | 0.68 | NOTUM (0.66) | NOTUMMAPTSMN1; SMN2P2RY14CYP2C9 | |
| SCHEMBL23852324 | 0.67 | NOTUM (0.70) | NOTUMSMN1; SMN2P2RY14CYP2C9TSPO | |
| SCHEMBL8577207 | 0.67 | NOTUM (0.70) | NOTUMMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515903-A1 | COMPOUNDS, PREPARATIONS AND USES THEREOF | Peter MacCallum Cancer Institute (AU) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011075784-A1 | COMPOUNDS, PREPARATIONS AND USES THEREOF | PETER MACCALLUM CANCER INSTITUTE (AU) | 2011-06-30 | — | — | WO | disclosed |