Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859663 | 0.88 | PLK1 (0.61) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL10110528 | 0.82 | PLK1 (0.55) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL195321 | 0.81 | HPGD (0.70) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL7090547 | 0.80 | CES2 (0.65) | PLK1LMNAHPGDHAO1ALDH1A1 | |
| SCHEMBL31626735 | 0.80 | PLK1 (0.53) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL7089334 | 0.80 | CES2 (0.70) | PLK1LMNAHPGDHAO1ALDH1A1 | |
| SCHEMBL11384642 | 0.79 | MAPT (0.49) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL11384640 | 0.79 | MAPT (0.49) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL31626804 | 0.78 | PLK1 (0.52) | PLK1LMNAHPGDL3MBTL1HAO1 | |
| SCHEMBL6050656 | 0.78 | CES2 (0.67) | PLK1LMNAHAO1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110914250-B | Novel process for synthesizing tilobaxib | 珂思玛股份公司 | 2023-06-27 | — | — | CN | claimed |
| EP-3609877-B1 | PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S P A (IT) | 2020-12-23 | — | — | EP | claimed |
| US-10807962-B2 | Process for the synthesis of firocoxib | COSMA S.P.A. (IT) | 2020-10-20 | — | — | US | claimed |
| US-20200102279-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S.P.A. (IT) | 2020-04-02 | — | — | US | claimed |
| CN-110914250-A | Novel process for synthesizing felicoxib | 珂思玛股份公司 | 2020-03-24 | — | — | CN | claimed |
| EP-3609877-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | Cosma S.p.A. (IT) | 2020-02-19 | — | — | EP | claimed |
| WO-2018188763-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S.P.A. (IT) | 2018-10-18 | — | — | WO | claimed |
| CN-110914250-B | Novel process for synthesizing tilobaxib | 珂思玛股份公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-110914250-B | Novel process for synthesizing tilobaxib | 珂思玛股份公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-3609877-B1 | PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S P A (IT) | 2020-12-23 | — | — | EP | disclosed |
| US-10807962-B2 | Process for the synthesis of firocoxib | COSMA S.P.A. (IT) | 2020-10-20 | — | — | US | disclosed |
| US-10807962-B2 | Process for the synthesis of firocoxib | COSMA S.P.A. (IT) | 2020-10-20 | — | — | US | disclosed |
| US-20200102279-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S.P.A. (IT) | 2020-04-02 | — | — | US | disclosed |
| US-20200102279-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S.P.A. (IT) | 2020-04-02 | — | — | US | disclosed |
| CN-110914250-A | Novel process for synthesizing felicoxib | 珂思玛股份公司 | 2020-03-24 | — | — | CN | disclosed |
| CN-110914250-A | Novel process for synthesizing felicoxib | 珂思玛股份公司 | 2020-03-24 | — | — | CN | disclosed |
| EP-3609877-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | Cosma S.p.A. (IT) | 2020-02-19 | — | — | EP | disclosed |
| EP-3609877-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | Cosma S.p.A. (IT) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018188763-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S.P.A. (IT) | 2018-10-18 | — | — | WO | disclosed |
| WO-2018188763-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | COSMA S.P.A. (IT) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200102279-A1 | NEW PROCESS FOR THE SYNTHESIS OF FIROCOXIB | PPOX, RIOX2, CYP4X1 | PLK1 2117/4885LMNA 3044/4885HPGD 277/4885 |
| US-10807962-B2 | Process for the synthesis of firocoxib | RIOX2, PPOX, CYP4X1 | PLK1 1792/4885LMNA 2851/4885HPGD 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.