Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 3/20 | 0.79 |
| ▸ | CRHBP | P24387 | 2/20 | 0.79 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.79 |
| ▸ | IGF1R | P08069 | 1/20 | 0.74 |
| ▸ | PIM1 | P11309 | 2/20 | 0.69 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.67 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.67 |
| ▸ | NAT1 | P18440 | 4/20 | 0.64 |
| ▸ | MYC | P01106 | 1/20 | 0.64 |
| ▸ | MAX | P61244 | 1/20 | 0.64 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.61 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535130 | 1.00 | PTP4A3 (0.79) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL12204299 | 1.00 | PTP4A3 (0.79) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL28965550 | 0.88 | PTP4A3 (1.00) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL18102957 | 0.86 | PTP4A3 (0.71) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL1249001 | 0.85 | IGF1R (1.00) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL30990562 | 0.85 | IGF1R (1.00) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL1249000 | 0.85 | IGF1R (1.00) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL13500140 | 0.83 | PTP4A3 (0.67) | PTP4A3CRHBPCRHR2IGF1RPIM1 | |
| SCHEMBL18102858 | 0.83 | PTP4A3 (0.75) | PTP4A3CRHBPCRHR2PIM1PLA2G1B | |
| SCHEMBL14899471 | 0.83 | PTP4A3 (0.75) | PTP4A3CRHBPCRHR2IGF1RPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200068890-A1 | HETEROCYCLIC INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY | LA TROBE UNIVERSITY (AU) | 2020-03-05 | — | — | US | disclosed |
| EP-3609494-A1 | HETEROCYCLIC INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY | La Trobe University (AU) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018187845-A1 | HETEROCYCLIC INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY | LA TROBE UNIVERSITY (AU) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200068890-A1 | HETEROCYCLIC INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY | DDC, ODC1, DDT | PTP4A3 4348/4885CRHBP 3856/4885CRHR2 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.