Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535653 | 0.89 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20534896 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20535048 | 0.85 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20535663 | 0.85 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20534839 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20535044 | 0.83 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20535671 | 0.82 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20535529 | 0.82 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20534973 | 0.82 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL20535680 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |