Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16506603 | 0.94 | HDAC6 (0.59) | HDAC6HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL16517508 | 0.92 | HDAC6 (0.56) | HDAC6HDAC3HDAC4HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL16506851 | 0.91 | HDAC6 (0.55) | HDAC6HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL3090215 | 0.82 | HDAC6 (0.71) | HDAC6HDAC3HDAC4HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL16507177 | 0.82 | LMNA (0.49) | HDAC6LMNAHPGDLOXL2EPHX1 | |
| SCHEMBL6963348 | 0.81 | LOXL2 (0.54) | KMT2AMEN1LOXL2EPHX1NPC1 | |
| SCHEMBL3031652 | 0.81 | LMNA (0.48) | HDAC6LMNAHPGDKMT2AMEN1 | |
| SCHEMBL21088372 | 0.81 | HDAC1 (0.67) | HDAC1LMNAKMT2AMEN1LOXL2 | |
| SCHEMBL20535887 | 0.81 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL19922142 | 0.81 | CYP4A11 (0.54) | HPGDKMT2AMEN1LOXL2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12472271-B2 | HDAC6 inhibitors and imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2025-11-18 | — | — | US | disclosed |
| EP-4397656-A2 | HDAC6 INHIBITORS AND IMAGING AGENTS | The General Hospital Corporation (US) | 2024-07-10 | — | — | EP | disclosed |
| EP-4397656-A2 | HDAC6 INHIBITORS AND IMAGING AGENTS | The General Hospital Corporation (US) | 2024-07-10 | — | — | EP | disclosed |
| US-20240148915-A1 | HDAC6 Inhibitors and Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2024-05-09 | — | — | US | disclosed |
| EP-3609864-B1 | HDAC6 INHIBITORS AND IMAGING AGENTS | MASSACHUSETTS GEN HOSPITAL (US) | 2024-03-13 | — | — | EP | disclosed |
| US-11890356-B2 | HDAC6 inhibitors and imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2024-02-06 | — | — | US | disclosed |
| US-20220133916-A1 | HDAC6 Inhibitors and Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2022-05-05 | — | — | US | disclosed |
| US-20220133916-A1 | HDAC6 Inhibitors and Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2022-05-05 | — | — | US | disclosed |
| US-11207431-B2 | HDAC6 inhibitors and imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| US-11207431-B2 | HDAC6 inhibitors and imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200054773-A1 | HDAC6 Inhibitors and Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2020-02-20 | — | — | US | disclosed |
| US-20200054773-A1 | HDAC6 Inhibitors and Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2020-02-20 | — | — | US | disclosed |
| EP-3609864-A1 | HDAC6 INHIBITORS AND IMAGING AGENTS | The General Hospital Corporation (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018191360-A1 | HDAC6 INHIBITORS AND IMAGING AGENTS | THE GENERAL HOSPITAL CORPORATION (US) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200054773-A1 | HDAC6 Inhibitors and Imaging Agents | HDAC1, HDAC6, HDAC11 | HDAC6 2/4885HDAC3 4/4885HDAC4 7/4885 |
| US-11207431-B2 | HDAC6 inhibitors and imaging agents | HDAC1, HDAC6, HDAC11 | HDAC6 2/4885HDAC3 4/4885HDAC4 7/4885 |
| US-20240148915-A1 | HDAC6 Inhibitors and Imaging Agents | HDAC1, HDAC6, HDAC11 | HDAC6 2/4885HDAC3 4/4885HDAC4 7/4885 |
| US-12472271-B2 | HDAC6 inhibitors and imaging agents | HDAC1, HDAC6, HDAC11 | HDAC6 2/4885HDAC3 4/4885HDAC4 7/4885 |
| US-11890356-B2 | HDAC6 inhibitors and imaging agents | HDAC1, HDAC6, HDAC11 | HDAC6 2/4885HDAC3 4/4885HDAC4 7/4885 |
| US-20220133916-A1 | HDAC6 Inhibitors and Imaging Agents | HDAC1, HDAC6, HDAC11 | HDAC6 2/4885HDAC3 4/4885HDAC4 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.