Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.31 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20536107 | 1.00 | SCN9A (0.37) | SCN9ATRPV1RAB9ANPC1KMT2A | |
| SCHEMBL20535968 | 0.91 | SCN9A (0.40) | SCN9ATRPV1RAB9ANPC1GPBAR1 | |
| SCHEMBL20535967 | 0.91 | SCN9A (0.40) | SCN9ATRPV1RAB9ANPC1GPBAR1 | |
| SCHEMBL20535751 | 0.79 | L3MBTL1 (0.38) | RAB9ANPC1KMT2AMEN1PLIN1 | |
| SCHEMBL20535753 | 0.79 | L3MBTL1 (0.38) | RAB9ANPC1KMT2AMEN1PLIN1 | |
| SCHEMBL20535590 | 0.73 | SCN9A (0.42) | SCN9ATRPV1RAB9ANPC1GPBAR1 | |
| SCHEMBL28463731 | 0.73 | GAA (0.38) | KMT2APTPN1MEN1LMNAMAPT | |
| SCHEMBL13484976 | 0.72 | MEN1 (0.43) | RAB9ANPC1KMT2AMEN1PLIN1 | |
| SCHEMBL22080767 | 0.71 | GAA (0.38) | KMT2APTPN1MEN1LMNAMAPT | |
| SCHEMBL22042075 | 0.71 | GAA (0.38) | KMT2APTPN1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |