Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.37 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.37 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535751 | 1.00 | L3MBTL1 (0.38) | L3MBTL1LMNAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL20536123 | 0.89 | L3MBTL1 (0.39) | L3MBTL1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL20536125 | 0.89 | L3MBTL1 (0.39) | L3MBTL1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL23709945 | 0.81 | LMNA (0.41) | L3MBTL1LMNAMAPTMEN1KMT2A | |
| SCHEMBL28463731 | 0.81 | GAA (0.38) | L3MBTL1LMNAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL20536109 | 0.79 | SCN9A (0.37) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL20536401 | 0.79 | MAPT (0.41) | L3MBTL1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL20536399 | 0.79 | MAPT (0.41) | L3MBTL1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL22080767 | 0.78 | GAA (0.38) | LMNAMAPTSMN1; SMN2TDP1GAA | |
| SCHEMBL22042074 | 0.78 | GAA (0.38) | LMNAMAPTSMN1; SMN2TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |