Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20537077 | 0.90 | USP30 (0.49) | KMT2ATDP1SMN1; SMN2MAPTNAMPT | |
| SCHEMBL20537054 | 0.87 | KMT2A (0.57) | KMT2ATDP1SMN1; SMN2MAPTIDO1 | |
| SCHEMBL1951535 | 0.84 | KMT2A (0.48) | KMT2ATDP1TMPRSS2POLBLMNA | |
| SCHEMBL20537300 | 0.84 | SMN1; SMN2 (0.53) | KMT2ATDP1SMN1; SMN2MAPTIDO1 | |
| SCHEMBL20536802 | 0.83 | KDM4E (0.53) | KMT2ATDP1SMN1; SMN2MAPTNAMPT | |
| SCHEMBL1788003 | 0.76 | SMN1; SMN2 (0.53) | KMT2ATDP1SMN1; SMN2MAPTIDO1 | |
| SCHEMBL1787760 | 0.74 | MAPT (0.50) | KMT2ATDP1SMN1; SMN2MAPTIDO1 | |
| SCHEMBL1787758 | 0.74 | HRH3 (0.53) | KMT2ATDP1SMN1; SMN2MAPTIDO1 | |
| SCHEMBL20537078 | 0.74 | HSD17B3 (0.53) | KMT2ATDP1SMN1; SMN2MAPTTMPRSS2 | |
| SCHEMBL20536415 | 0.73 | L3MBTL1 (0.53) | KMT2ATDP1SMN1; SMN2MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-B1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | JAPAN TOBACCO INC (JP) | 2018-10-24 | — | — | EP | claimed |