Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20537300 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ATDP1L3MBTL1MAPT | |
| SCHEMBL20537308 | 0.90 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2ATDP1L3MBTL1 | |
| SCHEMBL20537054 | 0.86 | KMT2A (0.57) | SMN1; SMN2KMT2ATDP1L3MBTL1MAPT | |
| SCHEMBL14871702 | 0.86 | KDM4E (0.60) | KDM4ESMN1; SMN2KMT2ATDP1MAPT | |
| SCHEMBL20536799 | 0.83 | KMT2A (0.53) | SMN1; SMN2KMT2ATDP1MAPTNAMPT | |
| SCHEMBL20536415 | 0.81 | L3MBTL1 (0.53) | SMN1; SMN2KMT2ATDP1L3MBTL1MAPT | |
| SCHEMBL1788003 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ATDP1L3MBTL1MAPT | |
| SCHEMBL20536797 | 0.77 | MAPT (0.61) | SMN1; SMN2MAPT | |
| SCHEMBL1950717 | 0.76 | KMT2A (0.49) | KDM4EKMT2ATDP1MAPTNPSR1 | |
| SCHEMBL14871708 | 0.76 | KDM4E (0.62) | KDM4ESMN1; SMN2KMT2ANPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-B1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | JAPAN TOBACCO INC (JP) | 2018-10-24 | — | — | EP | claimed |