Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.49 |
| ▸ | INSR | P06213 | 6/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.45 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20537443 | 0.92 | LRRK2 (0.47) | LRRK2INSRALKIGF1REGFR | |
| SCHEMBL20537247 | 0.92 | LRRK2 (0.54) | LRRK2INSRALKIGF1REGFR | |
| SCHEMBL20537296 | 0.91 | LRRK2 (0.58) | LRRK2ALKEGFRJAK2 | |
| SCHEMBL20537441 | 0.89 | LRRK2 (0.57) | LRRK2INSRALKIGF1REGFR | |
| SCHEMBL17644512 | 0.88 | LRRK2 (0.59) | LRRK2INSRALKIGF1REGFR | |
| SCHEMBL15022377 | 0.87 | LRRK2 (0.56) | LRRK2INSRALKIGF1REGFR | |
| SCHEMBL17644540 | 0.86 | LRRK2 (0.59) | LRRK2MKNK2 | |
| SCHEMBL17644564 | 0.84 | LRRK2 (0.51) | LRRK2INSRALKIGF1REGFR | |
| SCHEMBL20537313 | 0.84 | LRRK2 (0.55) | LRRK2ALKEGFRJAK2 | |
| SCHEMBL17644552 | 0.84 | ALK (0.49) | LRRK2INSRALKIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3075730-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2018-10-24 | — | — | EP | claimed |