Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20537247 | 0.93 | LRRK2 (0.54) | LRRK2ALKINSREGFRIGF1R | |
| SCHEMBL7455205 | 0.91 | LRRK2 (0.48) | LRRK2ALKEGFR | |
| SCHEMBL20537443 | 0.90 | LRRK2 (0.47) | LRRK2ALKINSREGFRIGF1R | |
| SCHEMBL20537246 | 0.89 | LRRK2 (0.49) | LRRK2ALKINSREGFRIGF1R | |
| SCHEMBL17644552 | 0.89 | ALK (0.49) | LRRK2ALKINSREGFRIGF1R | |
| SCHEMBL17644540 | 0.87 | LRRK2 (0.59) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL17644519 | 0.87 | LRRK2 (0.57) | LRRK2ALKINSRMAP3K9MKNK2 | |
| SCHEMBL20537306 | 0.87 | LRRK2 (0.49) | LRRK2ALK | |
| SCHEMBL17644537 | 0.86 | LRRK2 (0.59) | LRRK2ALKINSREGFRIGF1R | |
| SCHEMBL17644544 | 0.86 | LRRK2 (0.60) | LRRK2ALKINSREGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3075730-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2018-10-24 | — | — | EP | claimed |