Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.77 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.77 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ADK | P55263 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129816 | 0.88 | PPARG (0.77) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL2035066 | 0.88 | PPARG (0.84) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL7961226 | 0.86 | PPARG (0.80) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL8185081 | 0.84 | ADK (0.77) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL2036618 | 0.84 | PPARG (0.89) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL8155291 | 0.84 | ADK (0.77) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL8139461 | 0.83 | PPARG (0.75) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL8194177 | 0.83 | PPARG (0.75) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL2033391 | 0.82 | PPARG (0.82) | PPARGNR2E3NCOR2KMT2AKDM4E | |
| SCHEMBL8129819 | 0.82 | PPARG (0.73) | PPARGNR2E3NCOR2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| US-20130023491-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-01-24 | — | — | US | disclosed |
| EP-2513298-A2 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | President and Fellows of Harvard College (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075665-A2 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023491-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | ADK, AHCY, IAPP | PPARG 2375/4885NR2E3 4022/4885NCOR2 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.