SCHEMBL20538501

SCHEMBL20538501

CC(C)(CNC(=O)c1ccccc1O)Cc1ncccc1-c1ccc(-c2cnc(N)nc2)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.51
ALOX5AP P20292 19/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20538704 0.88 FEN1 (0.60) FEN1ALOX5AP
SCHEMBL21089055 0.75 FEN1 (0.68) FEN1ALOX5AP
SCHEMBL15916373 0.72 FEN1 (0.74) FEN1ALOX5AP
SCHEMBL4607563 0.71 KDM4E (0.41)
SCHEMBL15936697 0.71 FEN1 (0.80) FEN1ALOX5AP
SCHEMBL15915638 0.70 FEN1 (0.66) FEN1ALOX5AP
SCHEMBL15915749 0.70 FEN1 (0.60) FEN1ALOX5AP
SCHEMBL15917362 0.69 FEN1 (0.72) FEN1ALOX5AP
SCHEMBL19286167 0.69 FEN1 (0.71) FEN1ALOX5AP
SCHEMBL20538692 0.68 FEN1 (1.00) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-10-24 EP claimed