Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20538998 | 1.00 | KLKB1 (0.61) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18795838 | 0.99 | KLKB1 (0.61) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18796211 | 0.99 | KLKB1 (0.61) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL24316756 | 0.91 | KLKB1 (0.61) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| Lithium Ion SCHEMBL29536224 | 0.89 | KLKB1 (0.62) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL24316749 | 0.88 | KLKB1 (0.61) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18823654 | 0.87 | KLKB1 (0.51) | KLKB1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21953682 | 0.85 | BTK (0.58) | KLKB1BTKHSD17B10EGLN1 | |
| SCHEMBL20549655 | 0.84 | BTK (0.57) | KLKB1BTKHSD17B10EGLN1 | |
| SCHEMBL18794977 | 0.82 | BTK (0.58) | KLKB1BTKHSD17B10EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399961-B2 | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-09-03 | — | — | US | disclosed |
| US-20180305338-A1 | HETEROARYLCARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399961-B2 | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors | KLKB1, BDKRB1, BDKRB2 | KLKB1 1/4885RAB9A 2432/4885SMN1; SMN2 4631/4885 |
| US-20180305338-A1 | HETEROARYLCARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KLKB1, BDKRB1, BDKRB2 | KLKB1 1/4885RAB9A 2432/4885SMN1; SMN2 4631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.