Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017050 | 0.86 | SLC40A1 (0.40) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2164054 | 0.84 | PIK3CD (0.42) | LMNAL3MBTL1MAPTHTTPIK3CD | |
| SCHEMBL2012932 | 0.83 | ABCC1 (0.33) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2014980 | 0.83 | SLC40A1 (0.38) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2014977 | 0.83 | SLC40A1 (0.38) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2018108 | 0.82 | METAP2 (0.38) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2051951 | 0.81 | PIK3CD (0.35) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2012342 | 0.81 | MAPT (0.42) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2017831 | 0.81 | METAP2 (0.38) | METAP2LMNAMAPK1L3MBTL1MAPT | |
| SCHEMBL2015211 | 0.81 | AXL (0.32) | METAP2LMNAMAPK1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |