Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 9/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959597 | 0.91 | CCR2 (0.36) | GCKCHRM3RORC | |
| SCHEMBL1960340 | 0.90 | GCK (0.36) | GCKCHRM3 | |
| SCHEMBL1962132 | 0.88 | GCK (0.32) | GCKCHRM3RORC | |
| SCHEMBL1961245 | 0.88 | CHRM3 (0.33) | GCKCHRM3 | |
| SCHEMBL1960337 | 0.87 | GCK (0.33) | GCKCHRM3RORC | |
| SCHEMBL1959161 | 0.86 | GCK (0.33) | GCKCHRM3ALDH1A1 | |
| SCHEMBL27889561 | 0.86 | FKBP1A (0.32) | CHRM3 | |
| SCHEMBL27873097 | 0.86 | NR1H3 (0.30) | CHRM3 | |
| SCHEMBL1961501 | 0.77 | GCK (0.45) | GCKCHRM3ALDH1A1CYP2C19 | |
| SCHEMBL1962937 | 0.74 | GCK (0.40) | GCKCHRM3ALDH1A1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |