Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.40 |
| ▸ | CDK1 | P06493 | 9/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30579477 | 0.92 | CDK5 (0.40) | AHRCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL20542014 | 0.92 | CDK5 (0.40) | AHRCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL30579354 | 0.89 | AHR (0.43) | NTRK1AHRCDK5CDK5R1CDK1 | |
| SCHEMBL2356743 | 0.89 | AHR (0.43) | NTRK1AHRCDK5CDK5R1CDK1 | |
| SCHEMBL20557731 | 0.86 | CDK5 (0.41) | NTRK1AHRCDK5CDK5R1CDK1 | |
| SCHEMBL2316607 | 0.85 | CDK2 (0.44) | AHRCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL30315335 | 0.85 | CDK2 (0.44) | AHRCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL21240842 | 0.85 | CDK2 (0.42) | NTRK1AHRCDK5CDK5R1CDK1 | |
| SCHEMBL2358503 | 0.82 | CDK2 (0.43) | AHRCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL20981874 | 0.81 | CDK2 (0.45) | AHRCDK5CDK5R1CDK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831600-B | Indole AHR inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2023-10-17 | — | — | CN | disclosed |
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-11358969-B2 | Indole AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200331917-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2020-10-22 | — | — | US | disclosed |
| US-10689388-B1 | Indole AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3612030-A2 | INDOLE AHR INHIBITORS AND USES THEREOF | Kyn Therapeutics (US) | 2020-02-26 | — | — | EP | disclosed |
| US-10570138-B2 | Indole AHR inhibitors and uses thereof | KYN THERAPEUTICS (US) | 2020-02-25 | — | — | US | disclosed |
| CN-110831600-A | Indole AHR inhibitors and uses thereof | 金恩医疗公司 | 2020-02-21 | — | — | CN | disclosed |
| WO-2018195397-A2 | INDOLE AHR INHIBITORS AND USES THEREOF | KYN THERAPEUTICS (US) | 2018-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570138-B2 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | NTRK1 1355/4885AHR 1/4885CDK5 1931/4885 |
| US-11358969-B2 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | NTRK1 1355/4885AHR 1/4885CDK5 1931/4885 |
| US-20200331917-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | NTRK1 1355/4885AHR 1/4885CDK5 1931/4885 |
| US-10689388-B1 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | NTRK1 1355/4885AHR 1/4885CDK5 1931/4885 |
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | NTRK1 1355/4885AHR 1/4885CDK5 1931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.