Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051915 | 0.89 | NUDT1 (0.38) | LMNAMAPK1HTTSMN1; SMN2NUDT1 | |
| SCHEMBL2015901 | 0.89 | MAPK1 (0.48) | LMNAMAPK1HTTSMN1; SMN2SYK | |
| SCHEMBL2054227 | 0.80 | PIK3CD (0.41) | NUDT1BRAFSYKAPPGBA1 | |
| SCHEMBL2013861 | 0.78 | PIK3CD (0.54) | PIK3CDPIK3CG | |
| SCHEMBL2053387 | 0.78 | MAPK1 (0.44) | LMNAMAPK1HTTSMN1; SMN2GBA1 | |
| SCHEMBL2013295 | 0.77 | PIK3CD (0.53) | LMNAMAPK1HTTSMN1; SMN2SYK | |
| SCHEMBL17397134 | 0.77 | PIK3CD (0.41) | NUDT1BRAFPIK3CDPIK3CG | |
| SCHEMBL17397272 | 0.76 | PIK3CD (0.46) | PIK3CDPIK3CG | |
| SCHEMBL2016100 | 0.75 | MAP4K4 (0.40) | LMNAMAPK1HTTSMN1; SMN2SYK | |
| SCHEMBL2051140 | 0.75 | PIK3CD (0.45) | LMNAMAPK1HTTSMN1; SMN2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |