Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051915 | 0.89 | NUDT1 (0.38) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL2015901 | 0.89 | MAPK1 (0.48) | MAPK1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL2050742 | 0.88 | PIK3CD (0.42) | MAPK1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL2052398 | 0.79 | PIK3CD (0.44) | MAPK1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL2016187 | 0.78 | PIK3CD (0.48) | PIK3CDMAP4K4RPS6KB1AURKAPIK3CG | |
| SCHEMBL2054366 | 0.78 | LMNA (0.40) | MAPK1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL2016100 | 0.77 | MAP4K4 (0.40) | MAPK1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL2013295 | 0.77 | PIK3CD (0.53) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL2051140 | 0.75 | PIK3CD (0.45) | MAPK1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL2015662 | 0.74 | CYP11B1 (0.38) | TAAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |