Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.49 |
| ▸ | INSR | P06213 | 13/20 | 0.49 |
| ▸ | IGF1R | P08069 | 13/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 2/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CD74 | P04233 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20546956 | 0.88 | PTK2 (0.51) | ALKINSRIGF1RPTK2AURKA | |
| SCHEMBL20547119 | 0.85 | EGFR (0.43) | ALKPTK2ROS1EGFRJAK2 | |
| SCHEMBL19921065 | 0.85 | PTK2 (0.40) | ALKINSRIGF1RPTK2JAK2 | |
| SCHEMBL20546960 | 0.85 | KHK (0.35) | ALKINSRIGF1RLRRK2 | |
| SCHEMBL19921138 | 0.83 | PLK1 (0.40) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL19921093 | 0.82 | TTK (0.50) | ALKINSRIGF1RPTK2AURKA | |
| SCHEMBL19921084 | 0.82 | IRAK4 (0.34) | ALKINSRIGF1RPTK2FES | |
| SCHEMBL20546169 | 0.80 | IRAK4 (0.38) | JAK2ABL1LCKKITSRC | |
| SCHEMBL19921085 | 0.79 | PTK2 (0.56) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL20546935 | 0.78 | NLRP3 (0.42) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | ALK 1505/4885INSR 3191/4885IGF1R 4466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.