Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 15/20 | 0.50 |
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 9/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722165 | 0.80 | BCAT2 (0.47) | KDM4EMAPTHPGDCYP2C19CYP1A2 | |
| SCHEMBL7787418 | 0.76 | HDAC8 (0.43) | KDM4EHPGDCYP2C19CYP1A2CYP2C9 | |
| SCHEMBL9053835 | 0.74 | BCAT2 (0.49) | KDM4EMAPTHPGDCYP2C19CYP1A2 | |
| SCHEMBL3791252 | 0.68 | KDM4E (0.40) | KDM4EMAPTHPGDLMNAHSD17B10 | |
| SCHEMBL7325294 | 0.68 | KMO (0.49) | KDM4EHPGDCYP2C19CYP1A2HSD17B10 | |
| SCHEMBL6837382 | 0.67 | KDM1A (1.00) | KDM1AMAOBMAOARCOR1CYP2C19 | |
| SCHEMBL15137021 | 0.67 | KDM1A (1.00) | KDM1AMAOBMAOARCOR1CYP2C19 | |
| SCHEMBL526573 | 0.67 | KDM1A (1.00) | KDM1AMAOBMAOARCOR1CYP2C19 | |
| SCHEMBL23499962 | 0.67 | NSD2 (0.46) | KDM4EMAPTHPGDCYP2C19CYP1A2 | |
| SCHEMBL28539802 | 0.67 | KDM4E (0.51) | KDM4EMAPTHPGDCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018197583-A1 | USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2018-11-01 | — | — | WO | disclosed |