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Intermedine

Intermedine

SCHEMBL20548027

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 3/20 0.82
▸ MC5R P33032 2/20 0.82
▸ MC3R P41968 2/20 0.82
▸ MC1R Q01726 2/20 0.82
▸ C5AR1 P21730 2/20 0.70
▸ CTSL P07711 3/20 0.69
▸ CTSS P25774 3/20 0.69
▸ CTSK P43235 3/20 0.69
▸ CTSH P09668 1/20 0.69
▸ IL23R Q5VWK5 1/20 0.64
▸ CXCL8 P10145 5/20 0.63
▸ GLP1R P43220 4/20 0.63
▸ GCGR P47871 3/20 0.60
▸ NMBR P28336 1/20 0.60
▸ GRPR P30550 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Intermedine SCHEMBL22076809 1.00 MC4R (0.82) MC4RMC5RMC3RMC1RC5AR1
SCHEMBL29358645 1.00 MC4R (0.82) MC4RMC5RMC3RMC1RC5AR1
SCHEMBL29534172 0.98 MC4R (0.78) MC4RMC5RMC3RMC1RC5AR1
SCHEMBL29430238 0.96 MC4R (0.78) MC4RMC5RMC3RMC1RC5AR1
SCHEMBL29533733 0.96 MC4R (0.78) MC4RMC5RMC3RMC1RC5AR1
Afamelanotide SCHEMBL29419548 0.96 MC4R (0.81) MC4RMC5RMC3RMC1RC5AR1
Afamelanotide SCHEMBL22463810 0.96 MC4R (0.81) MC4RMC5RMC3RMC1RC5AR1
Afamelanotide SCHEMBL29352792 0.96 MC4R (0.81) MC4RMC5RMC3RMC1RC5AR1
Afamelanotide SCHEMBL22463811 0.96 MC4R (0.81) MC4RMC5RMC3RMC1RC5AR1
Afamelanotide SCHEMBL29533175 0.95 MC4R (0.80) MC4RMC5RMC3RMC1RC5AR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024030950-A2 COMPOSITIONS FOR THE TREATMENT OF DISEASE SIGHTSTREAM BIOTHERAPEUTICS, INC. (US) 2024-02-08 — — WO disclosed
WO-2024030977-A2 NOVEL MELANOCORTIN ANALOGS SIGHTSTREAM BIOTHERAPEUTICS, INC. (US) 2024-02-08 — — WO disclosed
EP-3865132-A1 METHODS AND COMPOSITIONS FOR REDUCING CORNEAL ENDOTHELIAL CELL LOSS The Schepens Eye Research Institute, Inc. (US) 2021-08-18 — — EP disclosed
US-20200188441-A1 METHODS AND COMPOSITIONS FOR REDUCING CORNEAL ENDOTHELIAL CELL LOSS THE SCHEPENS EYE RESEARCH INSTITUTE, INC. 2020-06-18 — — US disclosed
EP-3634416-A1 METHODS AND COMPOSITIONS FOR REDUCING CORNEAL ENDOTHELIAL CELL LOSS The Schepens Eye Research Institute, Inc. (US) 2020-04-15 — — EP disclosed
WO-2018201002-A1 METHODS AND COMPOSITIONS FOR REDUCING CORNEAL ENDOTHELIAL CELL LOSS THE SCHEPENS EYE RESEARCH INSTITUTE, INC. (US) 2018-11-01 — — WO disclosed
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