Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 4/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20548651 | 0.94 | P2RX7 (0.52) | P2RX7LMNAALDH1A1TAAR1IL1B | |
| SCHEMBL30314351 | 0.94 | P2RX7 (0.52) | P2RX7LMNAALDH1A1TAAR1IL1B | |
| SCHEMBL20548433 | 0.91 | P2RX7 (0.52) | P2RX7LMNAALDH1A1IL1BGAA | |
| SCHEMBL30314358 | 0.91 | P2RX7 (0.52) | P2RX7LMNAALDH1A1IL1BGAA | |
| SCHEMBL20548418 | 0.85 | P2RX7 (0.58) | P2RX7LMNAALDH1A1IL1BGAA | |
| SCHEMBL30314325 | 0.85 | P2RX7 (0.58) | P2RX7LMNAALDH1A1IL1BGAA | |
| SCHEMBL30314371 | 0.85 | LMNA (0.43) | P2RX7LMNAALDH1A1TAAR1DAO | |
| SCHEMBL20548605 | 0.85 | LMNA (0.43) | P2RX7LMNAALDH1A1TAAR1DAO | |
| SCHEMBL20551048 | 0.83 | P2RX7 (0.41) | P2RX7LMNAALDH1A1KMT2A | |
| SCHEMBL30314329 | 0.83 | P2RX7 (0.41) | P2RX7LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3398941-A1 | HETEROCYCLIC P2X7 ANTAGONISTS | AXXAM S.p.A. (IT) | 2018-11-07 | — | — | EP | claimed |