Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9237437 | 0.98 | BACE1 (0.61) | BACE1TAAR1GAAMAPTKMT2A | |
| SCHEMBL1021475 | 0.86 | AKR1B1 (0.54) | BACE1TAAR1GAAMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL1182809 | 0.84 | ADRA2A (0.55) | BACE1TAAR1GAAMAPTKMT2A | |
| SCHEMBL3935646 | 0.81 | KMT2A (0.58) | BACE1TAAR1GAAMAPTKMT2A | |
| SCHEMBL6022786 | 0.79 | TAAR1 (0.53) | BACE1TAAR1GAAMAPTKMT2A | |
| SCHEMBL21729216 | 0.79 | TAAR1 (0.53) | BACE1TAAR1GAAMAPTKMT2A | |
| SCHEMBL31459664 | 0.78 | HTR1D (0.44) | BACE1TAAR1GAAMAPK8SMN1; SMN2 | |
| SCHEMBL1285811 | 0.76 | AKR1B1 (0.74) | TAAR1GAAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL29570152 | 0.76 | AKR1B1 (0.74) | TAAR1GAAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1885453 | 0.76 | MAPT (0.59) | TAAR1GAAMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3398941-A1 | HETEROCYCLIC P2X7 ANTAGONISTS | AXXAM S.p.A. (IT) | 2018-11-07 | — | — | EP | disclosed |