Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31459659 | 0.79 | LMNA (0.42) | BACE1ACHEEEDTAAR1PKM | |
| SCHEMBL20548686 | 0.78 | BACE1 (0.63) | BACE1HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL9237437 | 0.76 | BACE1 (0.61) | BACE1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL19290092 | 0.76 | ACHE (0.41) | ACHEEEDPKMGAAALDH1A1 | |
| SCHEMBL28153560 | 0.76 | KDM4E (0.50) | ACHEGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6405863 | 0.74 | ACHE (0.48) | ACHEEEDTAAR1PKMGAA | |
| SCHEMBL2087457 | 0.74 | ACHE (0.48) | ACHEEEDTAAR1PKMGAA | |
| SCHEMBL22520955 | 0.72 | TAAR1 (0.59) | HTR1DACHETAAR1PKMSMN1; SMN2 | |
| SCHEMBL28724963 | 0.71 | SMN1; SMN2 (0.51) | GAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL31459639 | 0.71 | HDAC4 (0.35) | ACHEEEDPKMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096658-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096662-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |