SCHEMBL20548980

SCHEMBL20548980

O=C(O)NNC(=O)c1ccc2nn(-c3cccnc3)cc2c1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 4/20 0.46
ESR2 Q92731 1/20 0.46
RIPK2 O43353 2/20 0.42
MAPT P10636 5/20 0.41
ALDH1A1 P00352 3/20 0.41
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
MAPK1 P28482 1/20 0.41
NAMPT P43490 2/20 0.40
HTT P42858 1/20 0.39
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16569090 0.88 ADORA3 (0.42) ADORA3ESR2RIPK2ALDH1A1RAB9A
SCHEMBL29658143 0.88 ADORA3 (0.42) ADORA3ESR2RIPK2ALDH1A1RAB9A
SCHEMBL31457215 0.86 ESR2 (0.49) ADORA3ESR2RIPK2MAPTALDH1A1
SCHEMBL17802507 0.86 ESR2 (0.49) ADORA3ESR2RIPK2MAPTALDH1A1
SCHEMBL29617207 0.84 HTT (0.44) ADORA3ESR2RIPK2ALDH1A1RAB9A
SCHEMBL31568706 0.83 GRM1 (0.49) ADORA3ESR2RIPK2MAPT
SCHEMBL20548970 0.83 ADORA3 (0.43) ADORA3ESR2RIPK2MAPTALDH1A1
SCHEMBL20548985 0.82 ESR2 (0.45) ADORA3ESR2RIPK2MAPTALDH1A1
SCHEMBL19328774 0.82 MKNK1 (0.46) ADORA3ESR2ALDH1A1KDM4E
SCHEMBL29564697 0.82 MKNK1 (0.46) ADORA3ESR2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3601298-B1 PROCESS FOR PREPARING CHIRAL 2,3-DIHYDROTHIAZOLO[3,2-A]PYRIMIDIN-4-IUM COMPOUNDS BASF SE (DE) 2021-12-01 EP claimed
EP-3044220-B1 HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES FMC CORP (US) 2018-11-07 EP claimed
WO-2023203066-A1 SYNERGISTIC ACTION AS NITRIFICATION INHIBITORS OF DCD OLIGOMERS WITH ALKOXYPYRAZOLE AND ITS OLIGOMERS BASF SE (DE) 2023-10-26 WO disclosed
EP-3618628-A1 FUNGICIDAL MIXTURES COMPRISING TRIAZOLE COMPOUNDS BASF SE (DE) 2020-03-11 EP disclosed
WO-2018202737-A1 FUNGICIDAL MIXTURES COMPRISING TRIAZOLE COMPOUNDS BASF SE (DE) 2018-11-08 WO disclosed