Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | ACP1 | P24666 | 5/20 | 0.55 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30857514 | 0.87 | MAPT (0.75) | MAPTTP53POLBKMT2AMEN1 | |
| SCHEMBL20550980 | 0.87 | MAPT (0.75) | MAPTTP53POLBKMT2AMEN1 | |
| SCHEMBL21765569 | 0.85 | MEN1 (0.63) | MAPTTP53AGPAT2LMNAPOLB | |
| SCHEMBL3237409 | 0.83 | MAPT (0.67) | MAPTTP53ACP1AGPAT2LMNA | |
| SCHEMBL21750705 | 0.81 | MAPT (0.58) | MAPTTP53AGPAT2LMNAPOLB | |
| SCHEMBL12727986 | 0.81 | MAPT (0.65) | MAPTTP53ACP1AGPAT2LMNA | |
| SCHEMBL3235329 | 0.79 | MAPT (0.55) | MAPTTP53AGPAT2LMNAPOLB | |
| SCHEMBL7151679 | 0.79 | MAPT (0.62) | MAPTTP53ACP1LMNAKMT2A | |
| SCHEMBL5481520 | 0.78 | ESR1 (0.64) | MAPTLMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL13413895 | 0.78 | MAPT (0.61) | MAPTTP53ACP1AGPAT2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503456-B2 | Substituted pyrimidines and 1,3,5-triazines as RHOJ inhibitors | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-12-23 | — | — | US | disclosed |
| EP-3825310-B1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2025-11-12 | — | — | EP | disclosed |
| US-20240391898-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2024-11-28 | — | — | US | disclosed |
| CN-112279833-B | Trisubstituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2024-04-16 | — | — | CN | disclosed |
| US-11952366-B2 | Substituted 1,3,5-triazines as inhibitors for a rho family of GTP-ases | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2024-04-09 | — | — | US | disclosed |
| CN-110799505-B | Trisubstituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2022-08-30 | — | — | CN | disclosed |
| US-20220242848-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2022-08-04 | — | — | US | disclosed |
| US-11198682-B2 | Substituted pyrimidines as inhibitors for a Rho family of GTP-ases | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2021-12-14 | — | — | US | disclosed |
| US-11198682-B2 | Substituted pyrimidines as inhibitors for a Rho family of GTP-ases | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2021-12-14 | — | — | US | disclosed |
| EP-3619202-B1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2021-06-30 | — | — | EP | disclosed |
| EP-3619202-B1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2021-06-30 | — | — | EP | disclosed |
| EP-3825310-A1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | Fondazione Istituto Italiano di Tecnologia (IT) | 2021-05-26 | — | — | EP | disclosed |
| EP-3825310-A1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | Fondazione Istituto Italiano di Tecnologia (IT) | 2021-05-26 | — | — | EP | disclosed |
| CN-112279833-A | Tri-substituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2021-01-29 | — | — | CN | disclosed |
| EP-3619202-A1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | Fondazione Istituto Italiano di Tecnologia (IT) | 2020-03-11 | — | — | EP | disclosed |
| US-20200062733-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-02-27 | — | — | US | disclosed |
| US-20200062733-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-02-27 | — | — | US | disclosed |
| CN-110799505-A | Tri-substituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2020-02-14 | — | — | CN | disclosed |
| WO-2018203256-A1 | TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2018-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11952366-B2 | Substituted 1,3,5-triazines as inhibitors for a rho family of GTP-ases | CDC42, RHOA, TNK2 | MAPT 1329/4885TP53 2062/4885ACP1 932/4885 |
| US-12503456-B2 | Substituted pyrimidines and 1,3,5-triazines as RHOJ inhibitors | TNK2, CDC42, CDC42BPA | MAPT 878/4885TP53 1329/4885ACP1 996/4885 |
| US-20200062733-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | CDC42, RHOA, RHOT2 | MAPT 1372/4885TP53 1479/4885ACP1 2797/4885 |
| US-20240391898-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | CDC42, RHOA, RHOT2 | MAPT 1372/4885TP53 1479/4885ACP1 2797/4885 |
| US-11198682-B2 | Substituted pyrimidines as inhibitors for a Rho family of GTP-ases | CDC42, TNK2, ARHGEF1 | MAPT 1109/4885TP53 942/4885ACP1 594/4885 |
| US-20220242848-A1 | Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies | CDC42, RHOA, RHOT2 | MAPT 1372/4885TP53 1479/4885ACP1 2797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.