Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DDX3X | O00571 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21749269 | 0.89 | ABCG2 (0.46) | ABCG2TAS2R14ABCB1ATMTP53 | |
| SCHEMBL20552265 | 0.88 | ABCG2 (0.45) | ABCG2TAS2R14ABCB1ATMTP53 | |
| SCHEMBL20552643 | 0.88 | ABCG2 (0.47) | ABCG2TAS2R14ABCB1TP53MAPT | |
| SCHEMBL21749276 | 0.87 | ABCG2 (0.44) | ABCG2TAS2R14ABCB1ATMTP53 | |
| SCHEMBL20552347 | 0.86 | ABCG2 (0.46) | ABCG2TAS2R14ABCB1TP53MAPT | |
| SCHEMBL20552285 | 0.86 | ABCG2 (0.43) | ABCG2TAS2R14ABCB1ATMTP53 | |
| SCHEMBL25787252 | 0.86 | ABCG2 (0.43) | ABCG2TAS2R14ABCB1ATMTP53 | |
| SCHEMBL20552969 | 0.86 | ABCG2 (0.43) | ABCG2TAS2R14ABCB1ATMTP53 | |
| SCHEMBL25787257 | 0.86 | DDX3X (0.55) | ABCG2TAS2R14ABCB1MAPTSMN1; SMN2 | |
| SCHEMBL25787424 | 0.86 | TP53 (0.49) | ABCG2TAS2R14ABCB1ATMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3618818-A1 | NON-FUSED TRICYCLIC COMPOUNDS | Vivace Therapeutics, Inc. (US) | 2020-03-11 | — | — | EP | disclosed |
| WO-2018204532-A1 | NON-FUSED TRICYCLIC COMPOUNDS | VIVACE THERAPEUTICS, INC. (US) | 2018-11-08 | — | — | WO | disclosed |