Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.43 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21749276 | 0.90 | ABCG2 (0.44) | ABCG2DDX3XTAS2R14ABCB1ATM | |
| SCHEMBL20552285 | 0.89 | ABCG2 (0.43) | ABCG2DDX3XTAS2R14ABCB1ATM | |
| SCHEMBL20552347 | 0.89 | ABCG2 (0.46) | ABCG2DDX3XTAS2R14ABCB1TP53 | |
| SCHEMBL25787257 | 0.89 | DDX3X (0.55) | ABCG2DDX3XTAS2R14ABCB1MAPT | |
| SCHEMBL21749269 | 0.87 | ABCG2 (0.46) | ABCG2DDX3XTAS2R14ABCB1ATM | |
| SCHEMBL20552341 | 0.87 | DDX3X (0.44) | ABCG2DDX3XTAS2R14ABCB1ATM | |
| SCHEMBL20552265 | 0.86 | ABCG2 (0.45) | ABCG2DDX3XTAS2R14ABCB1ATM | |
| SCHEMBL20552643 | 0.86 | ABCG2 (0.47) | ABCG2DDX3XTAS2R14ABCB1TP53 | |
| SCHEMBL20552624 | 0.86 | ABCG2 (0.47) | ABCG2DDX3XTAS2R14ABCB1ATM | |
| SCHEMBL21749296 | 0.86 | DDX3X (0.43) | ABCG2DDX3XTAS2R14ABCB1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | ABCG2 2217/4885DDX3X 1986/4885TAS2R14 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.