SCHEMBL20553192

SCHEMBL20553192

CC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C.[NaH]

nearest known ligand 0.82

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 8/20 0.82
PGR P06401 4/20 0.80
NR3C1 P04150 3/20 0.80
HIF1A Q16665 7/20 0.79
KMT2A Q03164 2/20 0.79
AR P10275 3/20 0.72
CHRM1 P11229 2/20 0.72
CYP2C19 P33261 2/20 0.71
HSD17B10 Q99714 2/20 0.71
SERPINA6 P08185 2/20 0.71
CYP3A4 P08684 2/20 0.71
SHBG P04278 1/20 0.71
MAPT P10636 1/20 0.71
NFKB1 P19838 1/20 0.71
SMN1; SMN2 Q16637 1/20 0.71
LMNA P02545 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3049344 0.99 NR3C2 (0.84) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL321463 0.99 NR3C2 (0.84) NR3C2PGRNR3C1HIF1AKMT2A
Hydroxyurea SCHEMBL9938657 0.93 NR3C2 (0.75) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL11293782 0.91 NR3C2 (0.84) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL11584228 0.91 PGR (0.72) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL11582589 0.91 PGR (0.72) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL11582594 0.91 PGR (0.72) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL24966579 0.91 NR3C2 (0.82) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL28463036 0.91 NR3C2 (0.84) NR3C2PGRNR3C1HIF1AKMT2A
SCHEMBL14936105 0.90 NR3C2 (1.00) NR3C2PGRNR3C1HIF1AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
WO-2018204764-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION (US) 2018-11-08 WO disclosed