Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroxyurea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 8/20 | 0.75 |
| ▸ | PGR | P06401 | 4/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | AR | P10275 | 3/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | SHBG | P04278 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049344 | 0.94 | NR3C2 (0.84) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL321463 | 0.94 | NR3C2 (0.84) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL20553192 | 0.93 | NR3C2 (0.82) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL11293782 | 0.88 | NR3C2 (0.84) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL28463036 | 0.88 | NR3C2 (0.84) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL11582589 | 0.87 | PGR (0.72) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL11584228 | 0.87 | PGR (0.72) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL11582594 | 0.87 | PGR (0.72) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL24966579 | 0.86 | NR3C2 (0.82) | NR3C2PGRNR3C1HIF1AKMT2A | |
| SCHEMBL10597451 | 0.86 | NR3C2 (0.87) | NR3C2PGRNR3C1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012081038-A2 | ANTICANCER COMPOUNDS AND TARGETING CANCER WITH THE SAME | GODAVARI BIOREFINERIES LIMITED (IN) | 2012-06-21 | — | — | WO | disclosed |