Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20554113 | 0.86 | SMN1; SMN2 (0.52) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL24729359 | 0.77 | ALDH1A1 (0.74) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL29947610 | 0.77 | ALDH1A1 (0.74) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL261142 | 0.76 | SMN1; SMN2 (0.58) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL24729376 | 0.76 | MAPT (0.75) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL29947571 | 0.76 | MAPT (0.75) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5754836 | 0.75 | KDM4E (0.54) | KDM4ENPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL5756169 | 0.74 | KDM4E (0.53) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL20553950 | 0.73 | NPC1 (0.53) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8132 | 0.73 | KDM4E (1.00) | KDM4ETSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3401315-A1 | FXR RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR, AND USES THEREOF | Guangzhou Henovcom Bioscience Co. Ltd. (CN) | 2018-11-14 | — | — | EP | disclosed |