Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | SLC9A5 | Q14940 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | THPO | P40225 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768977 | 0.87 | TDP1 (0.43) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL29907694 | 0.87 | TDP1 (0.43) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL22551928 | 0.83 | NPSR1 (0.40) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL17778177 | 0.80 | ADORA2A (0.41) | ALDH1A1SLC9A1LMNAMEN1KMT2A | |
| SCHEMBL14237878 | 0.76 | PLAU (0.50) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL805324 | 0.74 | SCNN1A (0.63) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL31325583 | 0.74 | SCNN1A (0.63) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL17768824 | 0.72 | ADORA2A (0.43) | ALDH1A1CYP1A2TSHRCYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL11496167 | 0.72 | ALDH1A1 (0.65) | PLAUALDH1A1CYP1A2SLC9A1TSHR | |
| SCHEMBL17778186 | 0.72 | ADORA2A (0.39) | PLAUALDH1A1CYP1A2SLC9A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472347-B2 | Aminopyrazine compounds with A2A antagonist properties | MERCK SHARP & DOHME CORP. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180327385-A1 | AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME CORP. (US) | 2018-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472347-B2 | Aminopyrazine compounds with A2A antagonist properties | ADORA2A, ADORA1, ADORA3 | PLAU 2745/4885ALDH1A1 591/4885CYP1A2 603/4885 |
| US-20180327385-A1 | AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | ADORA2A, ADORA1, ADORA3 | PLAU 2745/4885ALDH1A1 591/4885CYP1A2 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.