Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.51 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551631 | 0.99 | APLNR (0.67) | APLNRHTR2AHTR2CCHRM2GRIN1 | |
| SCHEMBL2883792 | 0.95 | APLNR (0.71) | APLNRHTR2AHTR2CCHRM2GRIN1 | |
| SCHEMBL14971128 | 0.89 | APLNR (0.75) | APLNRHTR2AHTR2CTSHR | |
| SCHEMBL29580030 | 0.89 | APLNR (0.75) | APLNRHTR2AHTR2CTSHR | |
| SCHEMBL17138360 | 0.87 | APLNR (0.71) | APLNRHTR2AHTR2CCHRM2GRIN1 | |
| SCHEMBL7768853 | 0.86 | APLNR (0.86) | APLNRHTR2AHTR2CTSHRKDM4E | |
| SCHEMBL25386029 | 0.85 | APLNR (0.69) | APLNRHTR2AHTR2CCHRM2GRIN1 | |
| SCHEMBL7002432 | 0.85 | APLNR (0.73) | APLNRHTR2AHTR2CCHRM2GRIN1 | |
| SCHEMBL13739103 | 0.84 | APLNR (0.67) | APLNRHTR2AHTR2CCHRM2GRIN1 | |
| SCHEMBL918214 | 0.83 | APLNR (0.61) | APLNRHTR2AHTR2CCHRM2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018205948-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-11-15 | — | — | WO | disclosed |