Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.49 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.83 |
| ▸ | PTPRC | P08575 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | XIAP | P98170 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL28831604 | 1.00 | SLC7A5 (0.83) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL192543 | 0.98 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL29230366 | 0.98 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL192542 | 0.98 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL8934985 | 0.98 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL15689273 | 0.98 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL28873419 | 0.97 | SLC7A5 (0.83) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL5499765 | 0.95 | SLC7A5 (0.80) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL1931366 | 0.93 | SLC7A5 (0.96) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL124583 | 0.93 | SLC7A5 (0.96) | SLC7A5PTPRCPTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752709-B2 | Vinyl chloride-based polymer composition and method for producing the same | LG CHEM, LTD. (KR) | 2020-08-25 | — | — | US | disclosed |
| EP-3404051-B1 | VINYL CHLORIDE-BASED POLYMER COMPOSITION AND PREPARATION METHOD THEREFOR | LG CHEMICAL LTD (KR) | 2020-02-26 | — | — | EP | disclosed |
| US-20190055331-A1 | VINYL CHLORIDE-BASED POLYMER COMPOSITION AND METHOD FOR PRODUCING THE SAME | LG CHEM, LTD. (KR) | 2019-02-21 | — | — | US | disclosed |
| EP-3404051-A1 | VINYL CHLORIDE-BASED POLYMER COMPOSITION AND PREPARATION METHOD THEREFOR | LG Chem, Ltd. (KR) | 2018-11-21 | — | — | EP | disclosed |