Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.50 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.86 |
| ▸ | PTPRC | P08575 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL8934985 | 1.00 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL15689273 | 1.00 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL192542 | 1.00 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL29230366 | 1.00 | SLC7A5 (0.86) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL28873419 | 0.98 | SLC7A5 (0.83) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL28831604 | 0.98 | SLC7A5 (0.83) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL20558574 | 0.98 | SLC7A5 (0.83) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL5499765 | 0.97 | SLC7A5 (0.80) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL9715667 | 0.93 | SLC7A5 (0.80) | SLC7A5PTPRCPTGS1ALPIPKM | |
| Tyrosine SCHEMBL11676395 | 0.93 | SLC7A5 (1.00) | SLC7A5PTPRCPTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118688315-A | Multichannel high-coverage synchronous quantification method for amino-containing and hydroxyl-containing compounds | 复旦大学 | 2024-09-24 | — | — | CN | claimed |
| CN-116735770-A | Synchronous quantitative detection method for multiple metabolites in biological sample | 复旦大学 | 2023-09-12 | — | — | CN | claimed |
| CN-111378042-A | Cerenkov fluorescence imaging probe and preparation method and application thereof | 哈尔滨医科大学 | 2020-07-07 | — | — | CN | claimed |
| JP-7224089-A | — | — | None | — | — | JP | disclosed |
| CN-118688315-A | Multichannel high-coverage synchronous quantification method for amino-containing and hydroxyl-containing compounds | 复旦大学 | 2024-09-24 | — | — | CN | disclosed |
| CN-116735770-A | Synchronous quantitative detection method for multiple metabolites in biological sample | 复旦大学 | 2023-09-12 | — | — | CN | disclosed |
| CN-113354681-A | Asymmetric catalytic synthesis method of L-tyrosine derivative | 佛山奕安赛医药科技有限公司 | 2021-09-07 | — | — | CN | disclosed |
| WO-2021040422-A1 | NOVEL PYRIMIDO[4,5-D]PYRIMIDINE-2-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY | 한국과학기술연구원 | 2021-03-04 | — | — | WO | disclosed |
| CN-111378042-A | Cerenkov fluorescence imaging probe and preparation method and application thereof | 哈尔滨医科大学 | 2020-07-07 | — | — | CN | disclosed |
| CN-110423212-A | The inhibitor based on oxyindole carboxylic acid of SHP2 | UNIV INDIANA RES & TECH CORP | 2019-11-08 | — | — | CN | disclosed |
| CN-110199019-A | Analysis of Macromolecules Using Nucleic Acid Encoding | ENCODIA有限公司 | 2019-09-03 | — | — | CN | disclosed |
| WO-2001068655-A2 | CAPROLACTAM DERIVATIVES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2001-09-20 | — | — | WO | disclosed |
| CN-1234038-A | C-terminally modified (N-substituted) -2-indolyl dipeptides as inhibitors of ICE/ced-3 class of cysteine proteases | IDUN PHARMACEUTICALS INC (US) | 1999-11-03 | — | — | CN | disclosed |
| EP-0857721-A1 | ACRIDONE COMPOUNDS | Eisai Co., Ltd. (JP) | 1998-08-12 | — | — | EP | disclosed |
| US-5723576-A | POLYPEPTIDES FOR ENZYME INHIBITORS AND HIRUNDIN | DEVELOPMENT BIOTECHNOLOGICAL PROCESSES S.N.C. (IT) | 1998-03-03 | — | — | US | disclosed |
| US-5686310-A | Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0804470-A1 | THROMBIN INHIBITORS, THE PREPARATION THEREOF AND THE USE THEREOF FOR THERAPEUTICAL, PROPHYLACTIC AND DIAGNOSTIC APPLICATIONS | DEVELOPMENT BIOTECHNOLOGICAL PROCESSES S.N.C. DI PELLICCIA MARIA TERESA (IT) | 1997-11-05 | — | — | EP | disclosed |
| EP-0755941-A2 | Polypeptide and process for measuring living body components using the same | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1997-01-29 | — | — | EP | disclosed |
| JP-H07224089-A | STIMULATING FACTOR OF NEU RECEPTOR | YEDA RES & DEV CO LTD | 1995-08-22 | — | — | JP | disclosed |
| WO-1994024156-A1 | THROMBIN INHIBITORS, THE PREPARATION THEREOF AND THE USE THEREOF FOR THERAPEUTICAL, PROPHYLACTIC AND DIAGNOSTIC APPLICATIONS | DEVELOPMENT BIOTECHNOLOGICAL PROCESSES S.N.C. DI PELLICCIA MARIA TERESA (IT) | 1994-10-27 | — | — | WO | disclosed |