Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720952 | 0.89 | GAA (0.42) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| Isothiocyanate SCHEMBL1219403 | 0.88 | HSD11B1 (0.40) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL29467226 | 0.87 | KCNN4 (0.48) | MEN1KMT2AGAAALDH1A1HSD11B1 | |
| SCHEMBL5966718 | 0.87 | KCNN4 (0.48) | MEN1KMT2AGAAALDH1A1HSD11B1 | |
| SCHEMBL117692 | 0.87 | KCNN4 (0.48) | MEN1KMT2AGAAALDH1A1HSD11B1 | |
| SCHEMBL29057192 | 0.84 | KCNN4 (0.46) | MEN1KMT2AKDM4EALDH1A1HSD11B1 | |
| Benzene SCHEMBL29136712 | 0.84 | KCNN4 (0.52) | MEN1KMT2AKDM4EALDH1A1HSD11B1 | |
| SCHEMBL5607381 | 0.84 | KCNN4 (0.46) | MEN1KMT2AKDM4EALDH1A1HSD11B1 | |
| Ammonia Solution, Strong SCHEMBL15562823 | 0.84 | KCNN4 (0.46) | MEN1KMT2AKDM4EALDH1A1HSD11B1 | |
| SCHEMBL4463108 | 0.84 | KCNN4 (0.46) | MEN1KMT2AKDM4EALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110885298-B | Synthesis method of 4-chloro-3- (trifluoromethyl) phenylisocyanate | 山东金城医药化工有限公司 | 2022-05-10 | — | — | CN | claimed |
| WO-2022057164-A1 | PREPARATION METHOD FOR MULTI-TARGET ANTI-TUMOR DRUG | 广州南鑫药业有限公司 | 2022-03-24 | — | — | WO | claimed |
| CN-110885298-A | Synthesis method of 4-chloro-3- (trifluoromethyl) phenylisocyanate | 山东金城医药化工有限公司 | 2020-03-17 | — | — | CN | claimed |
| EP-3403651-B1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | LANZHOU INST CHEMICAL PHYSICS CAS (CN) | 2019-10-30 | — | — | EP | claimed |
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2018-11-22 | — | — | US | claimed |
| EP-3403651-A1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences (CN) | 2018-11-21 | — | — | EP | claimed |
| CN-102558144-A | Aryl urea derivatives | UNIV PEKING FOUNDER GROUP CO | 2012-07-11 | — | — | CN | claimed |
| CN-102532113-A | Aryl urea derivative | UNIV PEKING FOUNDER GROUP CO | 2012-07-04 | — | — | CN | claimed |
| CN-118108667-A | Preparation method of regorafenib | 南京法恩化学有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-116574035-B | Peach girder phenol derivative containing carbamate, preparation method and application | 扬州大学 | 2024-03-08 | — | — | CN | disclosed |
| CN-116574035-A | Peach girder phenol derivative containing carbamate, preparation method and application | 扬州大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-114380874-A | Macrolide antibiotics and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-04-22 | — | — | CN | disclosed |
| WO-2022057164-A1 | PREPARATION METHOD FOR MULTI-TARGET ANTI-TUMOR DRUG | 广州南鑫药业有限公司 | 2022-03-24 | — | — | WO | disclosed |
| CN-108148058-B | 4- (2-mercaptothiadiazole) substituted pyrimidine derivative, and preparation method and application thereof | 中国人民解放军第四军医大学 | 2021-03-16 | — | — | CN | disclosed |
| EP-3403651-A1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences (CN) | 2018-11-21 | — | — | EP | disclosed |
| CN-105008323-B | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof | 密歇根大学董事会 | 2018-11-06 | — | — | CN | disclosed |
| CN-108148058-A | A kind of pyrimidine derivatives preparation method of 4- (2- dimercaptothiodiazoles) substitution and application | 中国人民解放军第四军医大学 | 2018-06-12 | — | — | CN | disclosed |
| CN-102558144-A | Aryl urea derivatives | UNIV PEKING FOUNDER GROUP CO | 2012-07-11 | — | — | CN | disclosed |
| CN-102553642-A | Catalyst and preparation method for sorafenib intermediate | CEC MEDICAL TECHNOLOGY CO LTD | 2012-07-11 | — | — | CN | disclosed |
| CN-102532113-A | Aryl urea derivative | UNIV PEKING FOUNDER GROUP CO | 2012-07-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | CCND2, CCND3, IDH3A | MEN1 187/4885KMT2A 2096/4885KDM4E 3085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.