SCHEMBL20558689

SCHEMBL20558689

CCOc1cc(/C=C2\SC(=S)N(CC(=O)O)C2=O)ccc1O

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 1/20 0.81
MEN1 O00255 7/20 0.75
KMT2A Q03164 7/20 0.75
POLB P06746 4/20 0.75
GAA P10253 3/20 0.75
MAPT P10636 4/20 0.68
ALDH1A1 P00352 4/20 0.68
RECQL P46063 3/20 0.68
NPC1 O15118 1/20 0.68
THRB P10828 1/20 0.68
ALOX12 P18054 1/20 0.68
NPSR1 Q6W5P4 1/20 0.68
TDP1 Q9NUW8 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
MAPK1 P28482 3/20 0.67
PDE4B Q07343 1/20 0.66
AKR1B1 P15121 3/20 0.65
OPRK1 P41145 1/20 0.65
BLM P54132 1/20 0.65
ADAMTS5 Q9UNA0 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20558690 1.00 FABP4 (0.81) FABP4MEN1KMT2APOLBGAA
SCHEMBL24220168 0.90 FABP4 (1.00) FABP4MEN1KMT2APOLBGAA
SCHEMBL12008425 0.90 FABP4 (1.00) FABP4MEN1KMT2APOLBGAA
SCHEMBL9393527 0.89 PDE4B (0.78) FABP4MEN1KMT2APOLBMAPT
SCHEMBL29374482 0.89 PDE4B (0.78) FABP4MEN1KMT2APOLBMAPT
SCHEMBL2370857 0.89 PDE4B (0.78) FABP4MEN1KMT2APOLBMAPT
SCHEMBL12008736 0.88 FABP4 (0.89) FABP4MEN1KMT2APOLBGAA
SCHEMBL6884509 0.88 FABP4 (0.65) FABP4MEN1KMT2APOLBGAA
SCHEMBL18103056 0.86 MEN1 (1.00) FABP4MEN1KMT2APOLBGAA
SCHEMBL20558691 0.85 PTPN12 (0.64) FABP4KMT2APDE4BAKR1B1ADAMTS5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 US disclosed
EP-4584590-A1 PROXIMITY INDUCING SYSTEM AND USES THEREOF SORBONNE UNIVERSITE (FR) 2025-07-16 EP disclosed
WO-2024052353-A1 PROXIMITY INDUCING SYSTEM AND USES THEREOF SORBONNE UNIVERSITE (FR) 2024-03-14 WO disclosed
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES (FR) 2022-06-02 US disclosed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 EP disclosed
US-11162951-B2 Membrane-impermeant fluorogenic chromophores PARIS SCIENCES ET LETTRES (FR) 2021-11-02 US disclosed
US-11162951-B2 Membrane-impermeant fluorogenic chromophores PARIS SCIENCES ET LETTRES (FR) 2021-11-02 US disclosed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 WO disclosed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 EP disclosed
EP-3404022-B1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES LETTRES QUARTIER LATIN (FR) 2020-10-07 EP disclosed
EP-3404022-B1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES LETTRES QUARTIER LATIN (FR) 2020-10-07 EP disclosed
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2020-04-23 US disclosed
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2020-04-23 US disclosed
WO-2018211090-A1 MEMBRANE-IMPERMEABLE FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2018-11-22 WO disclosed
EP-3404022-A1 MEMBRANE-IMPERMEABLE FLUOROGENIC CHROMOPHORES Paris Sciences et Lettres - Quartier Latin (FR) 2018-11-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES QRFPR, BLVRB, IK FABP4 528/4885MEN1 3340/4885KMT2A 2506/4885
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF BLVRB, IK, HBG2 FABP4 1675/4885MEN1 3845/4885KMT2A 1217/4885
US-11162951-B2 Membrane-impermeant fluorogenic chromophores QRFPR, BLVRB, IK FABP4 528/4885MEN1 3340/4885KMT2A 2506/4885
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof BLVRB, HBG2, Q6ZSR9 FABP4 2642/4885MEN1 3100/4885KMT2A 1218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.