SCHEMBL20558928

SCHEMBL20558928

Cc1cc(/C=C2\SC(=S)N(CC(=O)O)C2=O)c(C)cc1O

nearest known ligand 0.62

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.62
▸ MEN1 O00255 3/20 0.62
▸ MAPT P10636 3/20 0.62
▸ PSMD14 O00487 1/20 0.62
▸ PKM P14618 1/20 0.62
▸ GFER P55789 1/20 0.62
▸ PTPN12 Q05209 1/20 0.54
▸ PTPN22 Q9Y2R2 1/20 0.54
▸ KDM4E B2RXH2 1/20 0.54
▸ ALDH1A1 P00352 1/20 0.54
▸ POLB P06746 1/20 0.54
▸ HPGD P15428 1/20 0.54
▸ AKR1B1 P15121 1/20 0.53
▸ PLG P00747 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20558930 1.00 KMT2A (0.62) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL7247695 0.91 KMT2A (0.66) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL7247692 0.91 KMT2A (0.66) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL6881330 0.85 KMT2A (0.61) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL6881328 0.85 KMT2A (0.61) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL20558641 0.82 PTPN12 (0.65) KMT2AMEN1PTPN12PTPN22POLB
SCHEMBL20558643 0.82 PTPN12 (0.65) KMT2AMEN1PTPN12PTPN22POLB
SCHEMBL7050939 0.81 PTPN12 (0.62) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL7050943 0.81 PTPN12 (0.62) KMT2AMEN1MAPTPSMD14PKM
SCHEMBL17769188 0.80 PTPN12 (0.59) KMT2AMEN1MAPTPSMD14PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 — — US disclosed
EP-4584590-A1 PROXIMITY INDUCING SYSTEM AND USES THEREOF SORBONNE UNIVERSITE (FR) 2025-07-16 — — EP disclosed
WO-2024052353-A1 PROXIMITY INDUCING SYSTEM AND USES THEREOF SORBONNE UNIVERSITE (FR) 2024-03-14 — — WO disclosed
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES (FR) 2022-06-02 — — US disclosed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 — — EP disclosed
US-11162951-B2 Membrane-impermeant fluorogenic chromophores PARIS SCIENCES ET LETTRES (FR) 2021-11-02 — — US disclosed
US-11162951-B2 Membrane-impermeant fluorogenic chromophores PARIS SCIENCES ET LETTRES (FR) 2021-11-02 — — US disclosed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 — — WO disclosed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 — — EP disclosed
EP-3404022-B1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES LETTRES QUARTIER LATIN (FR) 2020-10-07 — — EP disclosed
EP-3404022-B1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES LETTRES QUARTIER LATIN (FR) 2020-10-07 — — EP disclosed
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2020-04-23 — — US disclosed
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2020-04-23 — — US disclosed
WO-2018211090-A1 MEMBRANE-IMPERMEABLE FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2018-11-22 — — WO disclosed
EP-3404022-A1 MEMBRANE-IMPERMEABLE FLUOROGENIC CHROMOPHORES Paris Sciences et Lettres - Quartier Latin (FR) 2018-11-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES QRFPR, BLVRB, IK KMT2A 2506/4885MEN1 3340/4885MAPT 2381/4885
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF BLVRB, IK, HBG2 KMT2A 1217/4885MEN1 3845/4885MAPT 3026/4885
US-11162951-B2 Membrane-impermeant fluorogenic chromophores QRFPR, BLVRB, IK KMT2A 2506/4885MEN1 3340/4885MAPT 2381/4885
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof BLVRB, HBG2, Q6ZSR9 KMT2A 1218/4885MEN1 3100/4885MAPT 2357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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