Sugi Predict

Sugi Predict / Compounds / SCHEMBL20563124

SCHEMBL20563124

SCHEMBL20563124

COC(=O)Cc1ccc(Br)cc1OC(F)F

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ MEN1 O00255 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ MAPT P10636 1/20 0.38
▸ KDM4E B2RXH2 4/20 0.37
▸ ALDH1A1 P00352 2/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ PTGER1 P34995 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ RXFP1 Q9HBX9 1/20 0.36
▸ PKM P14618 1/20 0.35
▸ GAA P10253 2/20 0.35
▸ MGAM O43451 1/20 0.35
▸ SI P14410 1/20 0.35
▸ MGAM2 Q2M2H8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29737960 1.00 L3MBTL1 (0.38) L3MBTL1MEN1KMT2AMAPTKDM4E
SCHEMBL29737932 0.84 PTGDR2 (0.41) L3MBTL1MEN1KMT2AMAPTTDP1
SCHEMBL20562760 0.84 PTGDR2 (0.41) L3MBTL1MEN1KMT2AMAPTTDP1
SCHEMBL22918243 0.83 KDM4E (0.47) L3MBTL1MEN1KMT2AMAPTKDM4E
SCHEMBL29835995 0.83 KDM4E (0.47) L3MBTL1MEN1KMT2AMAPTKDM4E
SCHEMBL20562628 0.80 EPHX2 (0.45) L3MBTL1MEN1KMT2AKDM4ESMN1; SMN2
SCHEMBL22994473 0.79 HPGD (0.45) L3MBTL1MEN1KMT2AMAPTKDM4E
SCHEMBL20562112 0.79 NPY1R (0.42) MEN1KMT2AKDM4EALDH1A1
SCHEMBL502269 0.77 MAPT (0.48) L3MBTL1MAPTALDH1A1TDP1HPGD
SCHEMBL30154454 0.77 MAPT (0.48) L3MBTL1MAPTALDH1A1TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497382-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2025-12-16 — — US disclosed
US-11839613-B2 Pyrimidine derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2023-12-12 — — US disclosed
US-20230391747-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2023-12-07 — — US disclosed
US-11712438-B2 Phenyl derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2023-08-01 — — US disclosed
US-11702404-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2023-07-18 — — US disclosed
US-11702404-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2023-07-18 — — US disclosed
US-11702404-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2023-07-18 — — US disclosed
EP-4048664-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-08-31 — — EP disclosed
CN-114630823-A GLP-1R modulating compounds 吉利德科学公司 2022-06-14 — — CN disclosed
EP-3625222-B1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2021-07-21 — — EP disclosed
US-20210171499-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2021-06-10 — — US disclosed
WO-2021081207-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2021-04-29 — — WO disclosed
US-20210113559-A1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2021-04-22 — — US disclosed
US-20200179383-A1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS ACTELION PHARMACEUTICALS LTD (CH) 2020-06-11 — — US disclosed
EP-3625222-A1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS Idorsia Pharmaceuticals Ltd (CH) 2020-03-25 — — EP disclosed
EP-3625228-A1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS Idorsia Pharmaceuticals Ltd (CH) 2020-03-25 — — EP disclosed
CN-110612296-A Phenyl derivatives as PGE2 receptor modulators 爱杜西亚药品有限公司 2019-12-24 — — CN disclosed
CN-110612299-A Pyrimidine derivatives as PGE2 receptor modulators 爱杜西亚药品有限公司 2019-12-24 — — CN disclosed
WO-2018210994-A1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2018-11-22 — — WO disclosed
WO-2018210988-A1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2018-11-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11712438-B2 Phenyl derivatives as PGE2 receptor modulators PTGER1, PTGER4, PTGER2 L3MBTL1 4109/4885MEN1 4151/4885KMT2A 1790/4885
US-20200179383-A1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER1, PTGER4, PTGER2 L3MBTL1 4017/4885MEN1 4293/4885KMT2A 1625/4885
US-11702404-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 L3MBTL1 2918/4885MEN1 1966/4885KMT2A 3870/4885
US-11839613-B2 Pyrimidine derivatives as PGE2 receptor modulators PTGER1, PTGER4, PTGER2 L3MBTL1 4507/4885MEN1 4485/4885KMT2A 2391/4885
US-20210113559-A1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER1, PTGER4, PTGER2 L3MBTL1 4507/4885MEN1 4485/4885KMT2A 2391/4885
US-20230391747-A1 GLP-1R MODULATING COMPOUNDS GLP1R, GIPR, GPR119 L3MBTL1 2918/4885MEN1 1966/4885KMT2A 3870/4885
US-20210171499-A1 GLP-1R MODULATING COMPOUNDS GLP1R, GIPR, GPR119 L3MBTL1 2918/4885MEN1 1966/4885KMT2A 3870/4885
US-12497382-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 L3MBTL1 2918/4885MEN1 1966/4885KMT2A 3870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.