Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 5/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GLP1R | P43220 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056430 | 0.85 | SLC6A9 (0.46) | FLT1FLT4KDRSLC6A9 | |
| SCHEMBL13618870 | 0.85 | SLC6A9 (0.46) | FLT1FLT4KDRSLC6A9 | |
| SCHEMBL2054736 | 0.85 | SLC6A9 (0.46) | FLT1FLT4KDRSLC6A9 | |
| SCHEMBL2054781 | 0.78 | AKT1 (0.46) | NPC1RAB9AFLT1FLT4KDR | |
| SCHEMBL10234211 | 0.77 | SLC6A9 (0.66) | SLC6A9 | |
| SCHEMBL2054767 | 0.74 | MEN1 (0.46) | NPC1RAB9AFLT1FLT4KDR | |
| SCHEMBL2056444 | 0.74 | SLC6A9 (0.48) | FLT1FLT4KDRSLC6A9 | |
| SCHEMBL2056445 | 0.74 | SLC6A9 (0.48) | FLT1FLT4KDRSLC6A9 | |
| SCHEMBL2056425 | 0.74 | SLC6A9 (0.48) | FLT1FLT4KDRSLC6A9 | |
| SCHEMBL2056422 | 0.73 | SLC6A9 (0.70) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163956-B2 | Inhibitors of GLYT1 transporters | MERCK SHARP & DOHME CORP. (US) | 2012-04-24 | — | — | US | disclosed |