Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20565743 | 0.84 | POLB (0.52) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL29716338 | 0.83 | IDO1 (0.47) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL16000901 | 0.83 | IDO1 (0.47) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL17925754 | 0.81 | RAB9A (0.44) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL17372587 | 0.81 | POLB (0.49) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL20565791 | 0.81 | POLB (0.49) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL16003064 | 0.80 | XPO1 (0.48) | POLBALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL7234000 | 0.76 | MAPT (0.50) | POLBALDH1A1GAAMAPTATM | |
| SCHEMBL59779 | 0.76 | ALDH1A1 (0.51) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL16054857 | 0.75 | ALDH1A1 (0.48) | ALDH1A1GAAHTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157922-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS KINASE INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2018-11-28 | — | — | EP | disclosed |