Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.70 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | IDH1 | O75874 | 8/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917592 | 0.87 | HDAC3 (0.56) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL4915316 | 0.86 | HDAC3 (0.55) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL20685312 | 0.83 | IDH1 (0.78) | HDAC3HDAC1HDAC10HDAC6IDH1 | |
| SCHEMBL20685349 | 0.83 | IDH1 (0.76) | HDAC3HDAC1HDAC10HDAC6TP53 | |
| SCHEMBL18263886 | 0.83 | HDAC6 (1.00) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL24832713 | 0.83 | HDAC3 (0.67) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL18263885 | 0.83 | HDAC6 (1.00) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL26405543 | 0.82 | HDAC3 (0.82) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL26405542 | 0.82 | HDAC3 (0.82) | HDAC3HDAC1HDAC10HDAC6OGFRL1 | |
| SCHEMBL2724896 | 0.81 | HDAC6 (0.98) | HDAC3HDAC1HDAC10HDAC6OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108554-B | 1-cyclohexyl-2-phenylaminobenzimidazole as MIDH1 inhibitor for treating tumors | 德国癌症研究中心 | 2020-11-06 | — | — | CN | disclosed |
| CN-107108554-B | 1-cyclohexyl-2-phenylaminobenzimidazole as MIDH1 inhibitor for treating tumors | 德国癌症研究中心 | 2020-11-06 | — | — | CN | disclosed |
| US-10137110-B2 | 1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10137110-B2 | 1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors | HRH1, MDN1, MDH1 | HDAC3 933/4885HDAC1 272/4885HDAC10 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.